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The mixture of MPA with aminoglutethimide to deal with metastases from breast most cancers continues to be connected to a rise in depression.[28] St John's wort may possibly lessen the effectiveness of MPA like a contraceptive resulting from acceleration of its metabolism.[70]
If some time interval concerning injections is bigger than thirteen months, the medical professional need to establish the individual just isn't pregnant before administering the drug. The efficacy of Depo-Provera CI depends upon adherence to the dosage program of administration.
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It's not known if usage of Depo-Provera CI by more youthful Ladies will reduce peak bone mass and enhance the chance for osteoporotic fracture in later life.
Depo-Provera CI is indicated for your prevention of pregnancy and would hence be predicted to impair feminine fertility until finally cessation of therapy.
Medroxyprogesterone also results in variations inside your cervical mucus and uterine lining, rendering it tougher for sperm to get to the uterus and more durable for the fertilized egg to attach towards the uterus.
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The risk/good thing about lack of bone mineral density (BMD) in Females of all ages and the influence on peak bone mass in adolescents really should be regarded, along with the decrease in BMD that happens in the course of pregnancy and/or lactation, ought to be assessed when using Depo-Provera prolonged-term.
HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors: Sizeable adjustments (increase or lower) in the plasma amounts of progestin have been observed in some cases of co-administration of HIV protease inhibitors.
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If a affected person really should use added contraceptive safety when switching to DMPA from A further contraceptive strategy, think about continuing their former strategy for 7 times following DMPA injection. (As correct, see suggestions for Crisis Contraception.)